EN 
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RNDr. Miroslav Kubeš, CSc.
Managing director
BIOM-R, s.r.o. oversees two research, development and production laboratories as well as an e-shop
Animstem Laboratories
Animstem Laboratories – for research and development of therapeutic applications and production of stem cells for animal treatment. In our laboratory, which is licensed to produce personalized veterinary medicines, we process tissues rich in stem cells from our animal clients (e.g., adipose tissue). We isolate and freeze the cells or, if necessary, immediately multiply them according to the requirements of veterinarians for the treatment of their patients. This means that we prepare and store frozen stem cells for their potential use in the future, known as banking, because many diseases only manifest themselves at a later age. By cryopreservation, stem cells retain their ageless therapeutic potential. If an animal is already sick, we immediately multiply the isolated stem cells for planned therapeutic use. We also cryopreserve and store some of the stem cells from these dogs or cats for future therapeutic use (more at www.animstem.com).
Stem Cell Laboratory
Stem Cell Lab – for research into therapeutic applications and the preparation of stem cells for the treatment of human diseases. Last year, we obtained a license from the Slovak Ministry of Health to operate a human stem cell tissue facility. In this laboratory, we process donated perinatal tissues such as umbilical cord blood, umbilical cord tissue, and amniotic membrane for research and experimental therapeutic purposes. We also provide services for the isolation, freezing and storage of autologous mesenchymal stem cells from adipose tissue for future therapeutic use by clients.
Aweage
Aweage – an e-shop with longevity nutritional supplements (www.aweage.sk) is a premium e-shop with nutritional supplements offering scientifically proven supplements such as NMN, resveratrol, and betaine. Others are in preparation, such as Magtein, krill oil, berberine, quercetin, coenzyme Q10, spermidine, and other substances with the potential to slow down the aging process at the cellular level. In addition to the "longevity" series, we expect to have approximately 20 products in several series, such as "brain and memory," "metabolic health," and others.
Research and Development
Research Projects and Collaboration
We collaborate with several scientific research organizations in our research work. Our longest collaboration is with the Institute of Experimental Oncology at the Biomedical Center of the Slovak Academy of Sciences, where we have collaborated on several research projects using stem cells, mainly in the field of preleukemic clones in the umbilical cord blood of newborns. This collaboration has yielded original results that have been published in international scientific journals.
Below is a list of these publications:
Genetic instability in HSPC subpopulations of umbilical cord blood from patients with childhood acute lymphoblastic leukemia.
Vrobelova K, Jakl L, Skorvaga M, Kosik P, Durdik M, Markova E, Jakubikova J, Holop M, Kubes M, Cermak M, Puskacova J, Kolenova A, Belyaev I.Sci Rep. 2025 Mar 15;15(1):8953.
Induction of AML Preleukemic Fusion Genes in HSPCs and DNA Damage Response in Preleukemic Fusion Gene Positive Samples.
Kosik P, Durdik M, Skorvaga M, Klimova D, Kochanova D, Cerna Z, Kubes M, Holop M, Belyaev I. Antioxidants (Basel). 2021 Mar 18;10(3):481.
BCR/ABL preleukemic fusion gene in subpopulations of hematopoietic stem and progenitor cells from human UCB.
Jakl L, Skorvaga M, Beresova K, Kosik P, Durdik M, Jakubikova J, Holop M, Kubes M, Zastko L, Markova E, Beliaev I.Neoplasma. 2020 Jan;67(1):158-163. doi: 10.4149/neo_2019_190925N965. Epub 2019 Dec 23.
Backtracked analysis of preleukemic fusion genes and DNA repair foci in umbilical cord blood of children with acute leukemia.
Škorvaga M, Durdík M, Košík P, Marková E, Holop M, Kubeš M, Puškáčová J, Kolenová A, Belyaev I.Oncotarget. 2018 Apr 10;9(27):19233-19244.
Constitutive 53BP1/γH2AX foci are increased in cells of ALL patients dependent on BCR-ABL and TEL-AML1 preleukemic gene fusions.
Somsedikova A, Markova E, Kolenova A, Puskacova J, Kubes M, Belyaev I.Neoplasma. 2014;61(5):617-25.
Incidence of common preleukemic gene fusions in umbilical cord blood in Slovak population.
Škorvaga M, Nikitina E, Kubeš M, Košík P, Gajdošechová B, Leitnerová M, Copáková L, Belyaev I.PLoS One. 2014 Mar 12;9(3):e91116.
DNA damage response in CD133 + stem/progenitor cells from umbilical cord blood: low level of endogenous foci and high recruitment of 53BP1.
Vasilyev SA, Kubes M, Markova E, Belyaev I. Int J Radiat Biol. 2013 Apr;89(4):301-309.
Our laboratories are located in BIONT, a.s. building – a Slovak manufacturer of radiopharmaceuticals and a diagnostic PET center. Together with employees of BIONT, a.s. and the University of St. Cyril and Methodius in Trnava, we are working to develop a diagnostic and potentially also a theranostic tool using mesenchymal stem cells. We have presented our initial results only as a contribution to a student scientific conference.
Radiolabelling of human stem cells with copper-64 as biotracers for positron emission tomography.
Linda Machalová1, Martin Valica1, Vanda Adamcová1, Miroslav Kubeš2, Peter Kováč3, Miroslav Horník1, Zborník z Celoslovenskej študentskej vedeckej konferencie, 2022, UCM, Trnava
Another project, within the framework of the Memorandum of Cooperation with the Faculty of Pharmacy of Comenius University in Bratislava, is the development and preparation of eye drops based on stem cell products for dogs with cataracts. As part of the experiment, we prepared eye drops according to a pre-designed composition of regenerative eye instillation containing conditioned media from stem cell cultivation in accordance with good tissue practice procedures. [Guidance FDA, 2011]. The composition was optimized in terms of the solubility of individual components in the presence of other active components and the possibilities of aseptic preparation using bacterial filtration with a 0.22 µm membrane filter were technologically verified. After adjusting the pH to an acceptable physiological range of 5.8 to 11.4, the physicochemical properties (density, viscosity, and surface tension) and ex vivo irritancy on erythrocytes were evaluated.
Veterinary eye drops with a biological component: Miroslava Potúčková1, Desana Matušová1, Mária Raučinová1, Zuzana Valachová1, Miroslav Kubeš2 (1Comenius University, Faculty of Pharmacy, Dept. of Galenic Pharmacy, Bratislava, Slovakia; 2 BIOM-Research, s.r.o., Poster session TD P17, 40th TECHNOLOGY DAYS 11th – 12th of September 2025
Z nášho laboratória
Certifikáty a povolenia
Animcell laboratories sú prevádzkou spoločnosti BIOM-R, s.r.o. s Povolením na výrobu veterinárnych liekov č. 1048/2019-5000-V vydanom ÚŠKVBL (Ústav štátnej kontroly veterinárnych biopreparátov a liečiv) v Nitre a certifikátom Správnej výrobnej praxe (GMP).
Contact
BIOM-R, s.r.o.
RNDr. Miroslav Kubeš, CSc.
Nad lúčkami 41
841 05 Bratislava
+421 915 626 699
www.biom-r.com
Animstem Laboratories
Mgr. Marek Holop
Karloveská 63
842 29 Bratislava
www.animstem.com
Stem Cell Laboratory
Karloveská 63
842 29 Bratislava
+421 915 626 699
kubes@biom-r.com
www.sc-lab.eu